I'm pulling my very grey hair out of this one....
Standard AD, on-prem, 2012R2. File server is 2012, client is Win10. Application installed is Iris (Earnie).
Part of Iris is installed to the file share. This wouldn't usually be an issue with most software but we've had some interesting problems where parts of Iris do not work, specifically if you need to access the internet. Launching as Domain Admin works, all parts work. Launching as a local admin with network share mapped doesn't work. Launching as an end user, it doesn't work.
I've just had a 2 hour call with Iris who are pretty much washing their hands of it saying it's my issue as the app should work from the network share.
Any ideas of what to check? My GPOs are pretty vanilla.